My research focuss on two areas of ocular disease-cataract and glaucoma. As it relates to lens biology, I am currently studying growth factor initiated signaling pathways critical for the regulation of lens epithelial cell proliferation, elongation and differentiation. A specific focus in this broad area of research is to elucidate the role (s) played by small GTP-binding proteins of the Ras and Rho family, in signaling pathways important in normal lens function and physiology, and in processes underlying cataractogenesis. These studies will be conducted in both in vitro and in vivo models, using a combination of pharmacological and genetic approaches.
In the context of glaucoma, I am attempting to address the biochemical and molecular mechanisms involved in regulating ocular pressure in normal and glaucomatous eyes. Our laboratory is currently studying the cellular signaling pathways that control cell morphology, cytoskeletal reorganization, cell-cell barrier and secretion in the trabecular meshwork. The trabecular meshwork comprises the major tissue of aqueous outflow pathway and represents the site of regulation of intraocular pressure. The above questions are being examined in cell culture and organ culture model systems.
Education and Training
- Osmania University, Ph.D. 1989
Selected Grants and Awards
- Autophagy and Mechanotransduction in the Trabecular Meshwork
- Fiber Cell Membrane Organization-Role in Lens Architecture and Function
- Trabecular Meshwork Cytoskeletal Signaling-Regulation of Aqueous Humor Outflow
- Targeting Autotaxin for the treatment of glaucoma
- Evaluation of anti-fibrotic response of AR-13324 in human trabecular meshwork primary culture model system
- Fiber Cell Cytoskeletal Scaffolds-Role in Lens Architecture and Function
- Role of Rho Kinase in Aqueous Humor Outflow Pathway