Clinical Research - Duke Eye Center
Clinical Research

David Epstein, MD, MMM

My research is focused on developing novel specific treatments for glaucoma that are directed at the trabecular meshwork, the tissue that is known to be abnormal in glaucoma, causing increased resistance to outflow of aqueous humor from the anterior chamber of the eye.  Methods include modern cell biological and molecular techniques to study both the tissue and cells of the outflow pathway in vitro and in vivo.  There is an emphasis on the influence of the cytoskeleton on aqueous humor outflow function.  In addition, recent work of the laboratory has focused on gene expression during elevations of intraocular pressure or mechanical stretch, with the goal of identifying key homeostatic influences on aqueous humor outflow resistance that might lead to novel therapies for glaucoma.  A current hypothesis is that proteasome dysfunction might be involved in the cellular aging that leads to glaucoma. 
David L. Epstein, MD, MMM
Joseph A.C. Wadsworth Clinical Professor
and Chairman of the Department of Ophthalmology
Duke Eye Center
2351 Erwin Road, AERI Suite 3002
Durham, NC  27710
Phone: (919) 684-5846
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