Ophthalmology Clinical Trials

COMPREHENSIVE

 
Physician: R. Robin Vann, MD      
Title:  The Effect of Corneal Horizontal Diameter on Surgically-Induced Astigmatism in Cataract Surgery              
Protocol#:Pro00059555 
Contact Information: LaToya Greene latoya.greene@duke.edu            

CORNEA

 
Physician: Alan Carlson, MD
Title:  Therapeutic use of Intacs corneal ring segments for keratoconus under a Humanitarian Device Exemption (Intacs)
Protocol#: Pro00027346
Contact Information: Ana Garcia-Turner turner@duke.edu
 
Physician: Preeya Gupta, MD       
Title:  Outcomes of Dry Eye Therapies for Treatment of Evaporative Dry Eye Disease               
Protocol#: Pro00047708
Contact Information: Christina Bunn christina.frazier@duke.edu
 
Physician: Preeya Gupta, MD
Title: Cross-Sectional Study of the Prevalence of TGFBI Corneal Dystrophies
Protocol #: Pro00072884
Contact Information: Ana Garcia-Turner garci008@mc.duke.edu
 
Physician: Preeya Gupta, MD
Title: A phase 3, double-masked, randomized, controlled study to evaluate the safety and efficacy of KPI-121 1.0% ophthalmic suspension in subjects with post-surgical inflammation and pain 
Protocol #: Pro00070833
Contact Information: Ana Garcia-Turner garci008@mc.duke.edu
See more information on clinicaltrials.gov
 
Physician: Anthony Kuo, MD   
Title:  Variability of Landmark Based Keratometry (Verion) Compared to Standard Automated Keratometry               
Protocol#: Pro00066645 
Contact Information: Ana Garcia-Turner garci008@mc.duke.edu or LaToya Greene latoya.greene@duke.edu      

GLAUCOMA

 
Physician: Leon  Herndon, MD
Title:  The effect of scheduled ripcord removal on the outcomes of Baerveldt 350 implants 
Protocol#:Pro00047845 
Contact Information: Christina Bunn christina.frazier@duke.edu
See more information on clinicaltrials.gov 
 
Physician: Leon  Herndon, MD
Title:  The Effect of Sponge Versus No-Sponge Placement of Mitomycin-C on the Outcomes of Trabeculectomy with Ex-PRESS glaucoma filtration device              
Protocol#:Pro00048136
Contact Information: Christina Bunn christina.frazier@duke.edu
See more information on clinicaltrials.gov 

NEURO-OPHTHALMOLOGY                                                                                                    

 
Physician: Mays El-Dairi, MD       
Title:  Using Optical Coherence Tomography Imaging to Study Anterior Segment, Retina and Optic Nerve Development in Pediatric Eyes           
Protocol#:Pro00065236 
Contact Information: Sarah Jones jones439@mc.duke.edu 
           
Physician: M. Tariq Bhatti, MD
Title: A Phase 2/3, Randomized, Double-Masked, Sham-Controlled Trial of QPI-1007 Delivered By Single or Multi-Dose Intravitreal Injection(s) to Subjects With Acute Non Arteritic Anterior Ischemic Optic Neuropathy (NAION) 
Protocol #: Pro00067184
Contact Information: LaToya Greene latoya.greene@duke.edu

OCULOPLASTICS

No prospective trials at this time.


PEDIATRICS      

 

Physician: Sharon Freedman, MD              
Title:  Home use of Icare® rebound tonometry in children with known and suspected glaucoma 
Protocol#:Pro00070822 
Contact Information: Sarah Jones jones439@mc.duke.edu
 
Physician: Sharon Freedman, MD              
Title:  An Observational, Multicenter study of the Prevalence of Cerebrotendinous Xanthomatosis (CTX) in Patient Populations Diagnosed with Early-Onset Idiopathic Bilateral Cataracts 
Protocol#:Pro00070183 
Contact Information: Sarah Jones jones439@mc.duke.edu 
See more information on clinicaltrials.gov  

                                                                                           

 
Physician: Laura Enyedi, MD
Title:  SAS1: A Prospective Observational Study of Adult Strabismus             
Protocol#:Pro00065632 
Contact Information: Sarah Jones jones439@mc.duke.edu             
See more information on clinicaltrials.gov  
 
Physician: Sharon Freedman, MD              
Title:  A comparative study of iCare® rebound tonometry with other tonometry modalities in children with glaucoma and suspected of glaucoma           
Protocol#:Pro00019547 
Contact Information: Sarah Jones jones439@mc.duke.edu             
 
Physician: Sharon Freedman, MD              
Title:  The Use of Optical Coherence Tomography for the Evaluation of Visually Threatening Diseases             
Protocol#:Pro00029391 
Contact Information: Sarah Jones jones439@mc.duke.edu 
 
Physician: Grace Prakalapakorn, MD        
Title:  Adjustable Spectacles: Can Younger School-Aged Children Self-Refract Accurately?   
Protocol#:Pro00064775 
Contact Information: Sarah Jones jones439@mc.duke.edu

RETINA                                                                                     

 
Physician: Scott  Cousins, MD      
Title:  An Open-Label, Phase 1 Clinical Study to Evaluate the Safety and Tolerability of Subcutaneous Elamipretide in Subjects with Intermediate Age-Related Macular Degeneration
Protocol#:Pro00074019  
Contact Information: Kim Riley kimberly.riley@duke.edu
See more information on clinicaltrials.gov
 

Physician: Scott  Cousins, MD      
Title:  A Randomized, Double-Masked, Active-Controlled Phase 2 Study of the Efficacy, Safety, and Tolerability of Repeated Doses of Intravitreal REGN910-3 in Patients with Neovascular Age-Related Macular Degeneration
Protocol#:Pro00073900 
Contact Information: Kim Riley kimberly.riley@duke.edu
See more information on clinicaltrials.gov 

Physician: Scott  Cousins, MD      
Title:  A Phase 2b, Multicenter, Double-Masked, Randomized Study Evaluating the Safety and Clinical Response of Subretinal Administration of CNTO 2476 in Subjects with Visual Acuity Impairment Associated with Geographic Atrophy Secondary to Age Related Macular Degeneration
Protocol#:Pro00067112 
Contact Information: Kim Riley kimberly.riley@duke.edu
See more information on clinicaltrials.gov

Physician: Glenn J Jaffe, MD      
Title:  PeriOcular and INTravitreal corticosteroids for uveitic macular edema (POINT) Trial 
Protocol#:Pro00063755 
Contact Information: LaToya Greene latoya.greene@duke.edu
See more information on clinicaltrials.gov

Physician: Lajla Vajzovic, MD      
Title:  A Multicenter, Prospective Epidemiologic Study of the Progression of Geographic Atrophy Secondary to Age-Related Macular Degeneration 
Protocol#:Pro00067002 
Contact Information: Victoria Germann Victoria.germann@duke.edu or LaToya Greene latoya.greene@duke.edu
See more information on clinicaltrials.gov

 
Physician: Scott  Cousins, MD      
Title:  Neovascular Morphology and Persistent Disease Activity Among Patients with Neovascular Age-Related Macular Degeneration 
Protocol#:Pro00055232 
Contact Information: Kim Riley kimberly.riley@duke.edu
See more information on clinicaltrials.gov 
 
Physician: Scott  Cousins, MD
Title:  Adjunctive Photodynamic Therapy for Persistent Disease Activity in Patients with Neovascular Age-Related Macular Degeneration 
Protocol#:Pro00057705 
Contact Information: Kim Riley kimberly.riley@duke.edu
See more information on clinicaltrials.gov   
 
Physician: Scott  Cousins, MD
Title:  Prospective, Open-Label, Investigator-Initiated Study to Compare Adjunctive Verteporfin Photodynamic Therapy plus Intravitreal Aflibercept VS. Intravitreal Aflibercept Alone for the Treatment of Persistent Disease Activity in Patients with Neovascular Age-Related Macular Degeneration.   Protocol#:Pro00063930 
Contact Information: Kim Riley kimberly.riley@duke.edu  
See more information on clinicaltrials.gov
 
Physician:  Glenn Jaffe, MD
Title:  Pilot study of safety of fluocinolone acetonide intravitreal insert (FA-i) for the treatment of uveitis affecting the posterior segment.     IND #:  112891        
Protocol#:Pro00033019 
Contact Information: Cindy Skalak skala001@mc.duke.edu
See more information on clinicaltrials.gov  
 
Physician: Glenn Jaffe, MD              
Title:  A Controlled, Multi-Center Study of the Utilization and Safety of the MK II Inserter and the Safety of the FAI Insert in Subjects with Non-Infectious Uveitis Affecting the Posterior Segment of the Eye
Protocol#:Pro00068248 
Contact Information: Cindy Skalak skala001@mc.duke.edu
See more information on clinicaltrials.gov 
 
Physician: Eleonora Lad, MD, PhD             
Title:  Evaluation of visual function impairments in patients with dry age-related macular degeneration (AMD)       
Protocol#:Pro00036248 
Contact Information: Alice Ventura ventu006@mc.duke.edu
See more information on clinicaltrials.gov  
 
Physician: Eleonora Lad, MD, PhD             
Title:  A phase III multicenter, randomized, double-masked, sham-controlled study to assess the efficacy and safety of lampalizumab administered intravitreally to patients with geographic atrophy secondary to age related macular degeneration.      
Protocol#:Pro00055937 
Contact Information: Cecilia Santiago-Turla santi007@mc.duke.edu
See more information on clinicaltrials.gov  
 
Physician: Eleonora Lad, MD, PhD             
Title: A multicenter, prospective epidemiologic study of the progression of geographic atrophy secondary to age-related macular degeneration           
Protocol#:Pro00067002 
Contact Information: Alexandra Bosquet amg201@duke.edu
See more information on clinicaltrials.gov
 
Physician: Eleonora Lad, MD, PhD             
Title:  A Phase II, Multicenter, Randomized, Single-Masked, Sham-Controlled Study of Safety, Tolerability and Evidence of Activity of Intravitreal APL-2 Therapy in Patients Geographic Atrophy (GA) – FILLY       
Protocol#:Pro00066807 
Contact Information: Cecilia Santiago-Turla santi007@mc.duke.edu
See more information on clinicaltrials.gov
 
Physician: Priyatham Mettu, MD 
Title:  Remote Diagnosis of Retinal Disease           
Protocol#:Pro00057376
Contact Information: Kim Riley kimberly.riley@duke.edu
 
Physician: Priyatham Mettu, MD
Title:  Spectral Domain-Optical Coherence Tomography Angiography of Retinal Diseases               
Protocol#:Pro00063777 
Contact Information: Kim Riley kimberly.riley@duke.edu
See more information on clinicaltrials.gov 
 
Physician: Cynthia Toth, MD
Title:  Long working distance OCT system with fixation alignment for pediatric imaging Protocol#:Pro00060018
Contact Information: Neeru Sarin neeru.sarin@duke.edu
See more information on clinicaltrials.gov 
 
Physician: Cynthia Toth, MD        
Title:  Introperative OCT Guidance of Intraocular Surgery 
Protocol#:Pro00016827 
Contact Information: Neeru Sarin neeru.sarin@duke.edu
See more information on clinicaltrials.gov 
 
Physician: Cynthia Toth, MD        
Title:  Spectral Domain Optical Coherence Tomography Imaging of Infant Eyes: A Practical Diagnostic Tool and Methodology            
Protocol#:Pro00018146
Contact Information: Du Tran-Viet du.tran-viet@duke.edu             
 
PI: Daniel Saban, PhD
Title:  Analysis of polymorphonuclear leukocytes (PMN) mediators in patients with meibomian gland dysfunction 
Protocol #: Pro00068095
Contact Information:  Nancy Reyes, PhD nancy.reyes@dm.duke.edu

                                                                                                        

GERIATRICS &  OPHTHALMOLOGY                                                                                                      

 
Physician: Heather Whitson, MD
Title:  Novel Retinal Imaging Biomarkers in Early Alzheimer's Disease          
Protocol#:Pro00047227 
Contact Information: Cecilia Santiago-Turla santi007@mc.duke.edu
See more information on clinicaltrials.gov