Cornea, External Disease, and Refractive Surgery

Daniel Raphael Saban, PhD

Associate Professor of Ophthalmology

Assistant Professor in Immunology

Faculty Network Member of the Duke Institute for Brain Sciences

Education and Training

University of Florida, M.S. 2002
University of Florida, Ph.D. 2005
Harvard Medical School, Research Fellow, Schepens Eye Research Instittute
Harvard Medical School, Investigator, Immunology, Schepens Eye Research Institute
Harvard Medical School, Instructor, Ophthalmology

Selected Grants and Awards

Publications

BAFF promotes heightened BCR responsiveness and manifestations of chronic GVHD after allogeneic stem cell transplantation.

Patients with chronic graft-versus-host disease (cGVHD) have increased B cell-activating factor (BAFF) levels, but whether BAFF promotes disease after allogeneic bone marrow transplantation (allo-BMT) remains unknown.

In vivo quantitative analysis of anterior chamber white blood cell mixture composition using spectroscopic optical coherence tomography

Anterior uveitis is the most common form of intraocular inflammation, and one of its main signs is the presence of white blood cells (WBCs) in the anterior chamber (AC).

The cornea IV immunology, infection, neovascularization, and surgery chapter 1: Corneal immunology.

PURPOSE: of Review: This review offers an informed and up-to-date insight on the immune profile of the cornea and the factors that govern the regulation of such a unique immune environment.

Meibomian gland dysfunction is suppressed via selective inhibition of immune responses by topical LFA-1/ICAM antagonism with lifitegrast in the allergic eye disease (AED) model.

PURPOSE: The etiology of meibomian gland dysfunction (MGD) is incompletely understood, despite being a common ophthalmic condition and an area of unmet medical need.

Dysregulated transcriptional responses to SARS-CoV-2 in the periphery.

SARS-CoV-2 infection has been shown to trigger a wide spectrum of immune responses and clinical manifestations in human hosts.

Disease-Specific Expression of Conjunctiva Associated Lymphoid Tissue (CALT) in Mouse Models of Dry Eye Disease and Ocular Allergy.

Conjunctiva-associated tissue (CALT) is assumed to play a crucial role in the immune system of the ocular surface. Its function in several ocular surface diseases (OSD) is still not fully understood.

Daniel Raphael Saban, PhD

Education and Training

Selected Grants and Awards

Publications

BAFF promotes heightened BCR responsiveness and manifestations of chronic GVHD after allogeneic stem cell transplantation.

In vivo quantitative analysis of anterior chamber white blood cell mixture composition using spectroscopic optical coherence tomography

The cornea IV immunology, infection, neovascularization, and surgery chapter 1: Corneal immunology.

Meibomian gland dysfunction is suppressed via selective inhibition of immune responses by topical LFA-1/ICAM antagonism with lifitegrast in the allergic eye disease (AED) model.

Dysregulated transcriptional responses to SARS-CoV-2 in the periphery.

Disease-Specific Expression of Conjunctiva Associated Lymphoid Tissue (CALT) in Mouse Models of Dry Eye Disease and Ocular Allergy.

Microglia versus Monocytes: Distinct Roles in Degenerative Diseases of the Retina

The Immunological Basis of Dry Eye Disease and Current Topical Treatment Options.

Neutrophil L-Plastin Controls Ocular Paucibacteriality and Susceptibility to Keratitis

Large-scale death of retinal astrocytes during normal development is non-apoptotic and implemented by microglia.

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