Saban Lab Publications
Naturally occurring cell death is a fundamental developmental mechanism for regulating cell numbers and sculpting developing organs.
Whether complement dysregulation directly contributes to the pathogenesis of peripheral nervous system diseases, including sensory neuropathies, is unclear.
Progressive rod-cone degeneration (PRCD) is a small protein residing in the light-sensitive disc membranes of the photoreceptor outer segment.
In the eye immune defenses must take place in a plethora of differing microenvironments ranging from the corneal and conjunctival epithelia facing the external environment to the pigmented connective tissue of the uveal tract containing smooth mus
Microglia from different nervous system regions are molecularly and anatomically distinct, but whether they also have different functions is unknown.
Severe, chronic eye allergy is an understudied, vision-threatening condition. Treatments remain limited.
With the new understanding that adult microglia in mice have embryonic origins and are maintained in situ throughout life, it has become pertinent to now understand how these unique cells differ from monocyte-derived macrophages.
As the resident macrophages of central nervous system, microglia reside in the plexiform and nerve fiber layers of the retina.
Graft-versus-host disease (GVHD) is a major complication of hematopoietic stem cell transplantation (HCT). The tyrosine kinase SYK contributes to both acute and chronic GVHD development, making it an attractive target for GVHD prevention.
The number of neurons dedicated to vision itself is thought to be greater than the sum of the four other senses combined.