Skiba Laboratory

2351 Erwin Road, DUMC 3802

Nikolai Skiba, PhD, Principal Investigator

Nikolai Skiba, PhD
Assistant Professor
Duke Eye Center
2351 Erwin Road, DUMC 3802
AERI Room 5006 
Durham, NC  27710
Phone: (919) 668-5621

My research focuses on applying mass spectrometry based proteomics to study proteins in eye tissues, cells and sub-cellular compartments to understand mechanisms of vision. An important aspect of my research is to identify proteins in different compartments of retinal photoreceptor cells, their amount and modification status at different cell states defined by the light conditions, genotype, disease etc. This information can be valuable in understanding molecular mechanisms of vision and biology of the photoreceptor cell. Another important aspect of my research is to assist basic scientist and clinicians in our department in their proteomic needs which include identification of proteins and other biomolecules in a given biological sample, detection of protein post-translational modifications and sequence variations, elucidation of protein-protein interactions and also characterization of changes in the protein concentration and composition in a biological sample at different conditions.