W. Daniel Stamer, PhD, Principal Investigator
Joseph A.C. Wadsworth Professor of Ophthalmology
Professor of Biomedical Engineering
Duke Eye Center
2351 Erwin Road
AERI Rm 4008
Durham, NC 27710
Postdoctoral Fellow: Department Of Ophthalmology, Duke University School of Medicine 1997 - 1998
Postdoctoral Fellow: Physiology And Pharmacology/Toxicology Departments, University of Arizona College of Medicine 1996 - 1997
Ph.D.: University of Arizona 1996
B.S.: University of Arizona 1990
The Pathobiology of Ocular Hypertension in Glaucoma
My laboratory studies the disease of glaucoma, the second leading cause of blindness in the United States, affecting nearly 3 million people (70 million Worldwide). The primary risk factor for developing glaucoma is ocular hypertension (high intraocular pressure, IOP). IOP is a function of aqueous humor moving into and out of the eye. Elevated IOP in glaucoma is a result of disease in the primary efflux route, the conventional outflow pathway, affecting proper drainage of aqueous humor.
Lowering IOP in glaucoma patients, whether or not they have ocular hypertension, is important because large clinical trials involving tens of thousands of patients repeatedly demonstrate that significant, sustained IOP reduction slows or halts vision loss. Unfortunately, current first-line medical treatments do not target the diseased conventional pathway and do not lower IOP sufficiently in most people with glaucoma. Therefore, finding new, more effective ways to medically control IOP by targeting the conventional pathway is a central goal the Stamer Laboratory.
Using molecular, cellular, organ and mouse model systems, my laboratory seeks to identify and validate novel drug targets in the human conventional outflow pathway such that novel treatment of ocular hypertension and glaucoma can be developed.