Over the last quarter century, optical coherence tomography (OCT) technology has developed in amazing ways—and a multidisciplinary team at Duke University is responsible for much of that development.
We are honored to announce that Duke Ophthalmology and Biomedical Engineering were invited to publish three papers in Investigative Ophthalmology and Vision Sciences (IOVS) special issue to celebrate the 25th anniversary of OCT.
Optical Coherence Tomography for Retinal Surgery: Perioperative Analysis to Real-Time Four-Dimensional Image-Guided Surgery
Oscar M. Carrasco-Zevallos; Brenton Keller; Christian Viehland; Liangbo Shen; Michael I. Seider; Joseph A. Izatt; Cynthia A. Toth
Magnification of the surgical field using the operating microscope facilitated profound innovations in retinal surgery in the 1970s, such as pars plana vitrectomy. Although surgical instrumentation and illumination techniques are continually developing, the operating microscope for vitreoretinal procedures has remained essentially unchanged and currently limits the surgeon's depth perception and assessment of subtle microanatomy. Optical coherence tomography (OCT) has revolutionized clinical management of retinal pathology, and its introduction into the operating suite may have a similar impact on surgical visualization and treatment. In this article, we review the evolution of OCT for retinal surgery, from perioperative analysis to live volumetric (four-dimensional, 4D) image-guided surgery. We begin by briefly addressing the benefits and limitations of the operating microscope, the progression of OCT technology, and OCT applications in clinical/perioperative retinal imaging. Next, we review intraoperative OCT (iOCT) applications using handheld probes during surgical pauses, two-dimensional (2D) microscope-integrated OCT (MIOCT) of live surgery, and volumetric MIOCT of live surgery. The iOCT discussion focuses on technological advancements, applications during human retinal surgery, translational difficulties and limitations, and future directions. Read the full article
Impact of Microscope-Integrated OCT on Ophthalmology Resident Performance of Anterior Segment Surgical Maneuvers in Model Eyes
Bozho Todorich; Christine Shieh; Philip J. DeSouza; Oscar M. Carrasco-Zevallos; David L. Cunefare; Sandra S. Stinnett; Joseph A. Izatt; Sina Farsiu; Privthi Mruthyunjaya; Anthony N. Kuo; Cynthia A. Toth
This study evaluated the impact of swept-source optical coherence tomography (SS-OCT) on ophthalmology residents' performance of ophthalmic microsurgical maneuvers. The study concluded that microscope-integrated OCT feedback enhances performance of ophthalmology residents in select anterior segment surgical maneuvers. Microscope-integrated OCT represents a valuable tool in the surgical education of ophthalmology residents. Read the full article
Posterior Eye Shape Measurement With Retinal OCT Compared to MRI
Anthony N. Kuo; Pavan K. Verkicharla; Ryan P. McNabb; Carol Y. Cheung; Saima Hilal; Sina Farsiu; Christopher Chen; Tien Y. Wong; M. Kamran Ikram; Ching Y. Cheng; Terri L. Young; Seang M. Saw; Joseph A. Izatt
Dr. Anthony Kuo and colleagues evaluated the use of optical coherence tomography (OCT) as an alternate for magnetic resonance imaging (MRI) for assessment of posterior eye shape to study myopia. This study provides evidence that with distortion correction, noninvasive office-based OCT could potentially be used instead of MRI for the study of posterior eye shape. Read the full article