Machine learning model identifies mild cognitive impairment from retinal scans, Duke Health Press Release

Machine learning model identifies mild cognitive impairment from retinal scans

A new ML model can identify mild cognitive impairment from retinal scans

Eye scans could offer early warning signs of Alzheimer’s disease, Duke researchers find

Eye to the Mind: AI Pinpoints Cognitive Impairment via Retinal Images

Can You See Alzheimer Disease with Retina Scan?

Retinal OCT Shows Promise as Diagnostic Aid for Mild Cognitive Impairment

Duke Health Researchers Make Advancements in Eye Health

OCT/OCTA ocular biomarkers may help diagnose Parkinson disease

A Convolutional Neural Network Using Multimodal Retinal Imaging for Differentiation of Mild Cognitive Impairment from Normal Cognition

Convolutional Neural Network-Based Automated Quality Assessment of OCT and OCT Angiography Image Maps in Individuals with Neurodegenerative Disease

Retinal Vascular Changes in Alzheimer’s Dementia and Mild Cognitive Impairment: A Pilot Study Using Ultra-widefield Imaging

Intrasession Repeatability of Optical Coherence Tomography Angiography Parameters in Neurodegenerative Disease

The Application of Optical Coherence Tomography Angiography in Alzheimer's Disease: A Systematic Review

Assessment of Differences in Retinal Microvasculature Using OCT Angiography in Alzheimer's Disease: A Twin Discordance Report

Assocation of OCTA parameters with Age in Cognitively Healthy Older Adults

Choroidal Vascularity Index: A Step Towards Software as a Medical Device

Correlation of OCTA and Volumetric MRI in Mild Cognitive Impairment and Alzheimer's Disease

Is OCT Angiography Useful in Neurodegenerative Diseases?

Repeatability of Peripapillary Optical Coherence Tomography Angiography Parameters in Older Adults

Retinal Microvasculature and Neurodegenerative Changes in Alzheimer's Disease and Mild Cognitive Impairment Compared with Control Participants

Structural and Functional Retinal Changes in Preclinical Alzheimer Disease

Choroidal Structural Analysis in Alzheimer Disease, Mild Cognitive Impairment, and Cognitively Healthy Controls

Convolutional neural network to identify symptomatic Alzheimer's disease using multimodal retinal imaging

Characterization of Retinal Microvascular and Choroidal Structural Changes in Parkinson Disease

Assessing the Retinal Microvasculature in Individuals With Early and Late-Onset Alzheimer's Disease

Identifying Peripapillary Radial Capillary Plexus Alterations in Parkinson's Disease Using OCT Angiography

Retinal and Choroidal Changes in Men Compared with Women with Alzheimer’s Disease

Repeatability of Peripapillary OCT Angiography in Neurodegenerative Disease

Assessment of retinal microvascular alterations in individuals with amnestic and non-amnestic mild cognitive impairment using optical coherence tomography angiography

Artificial intelligence in dementia.

Longitudinal Analysis of the Retina and Choroid in Cognitively Normal Individuals at Higher Genetic Risk of Alzheimer Disease

Standardization in Ophthalmic Imaging

Differences in Retinal and Choroidal Microvasculature and Structure in Dementia With Lewy Bodies Compared With Normal Cognition

Longitudinal analysis of retinal microvascular and choroidal imaging parameters in Parkinson’s disease compared to controls. 

Peripapillary optical coherence tomography angiography in Alzheimer’s disease, mild cognitive impairment, and normal cognition. 

Ultra-widefield imaging of the retinal macrovasculature in Parkinson disease vs controls with normal cognition using alpha-shapes analysis.

Characterizing differences in retinal and choroidal vasculature and structure in individuals with Huntington’s disease compared to healthy controls: a cross-sectional prospective study. 

Analysis of the retinal and choroidal vasculature using ultra-widefield fundus imaging in mild cognitive impairment and normal cognition.

Longitudinal retinal and choroidal image analysis in a set of monozygotic twins. 

Macular, choroidal and peripapillary perfusion changes in traumatic brain injury. 

A longitudinal assessment of peripapillary microvasculature using optical coherence tomography angiography in cognitively normal adults. 

Presentation to US Senate Special Committee on Aging - April 2, 2019

Polascik BW, Yoon S, Grewal DS, Hoffmeyer GC, Fekrat S. Assessment of differences in retinal microvasculature using optical coherence tomography angiography in Alzheimer’s disease: a twin discordance report.  North Carolina Society of Eye Physicians and Surgeons Annual Meeting, Hot Springs, Virginia. 

Yoon SP, Grewal DS, Polascik BW, Burke JP, Fekrat S. Comparison of retinal microvasculature and neurodegenerative changes among Alzheimer’s Disease, Mild Cognitive Impairment, and Controls. ARVO 2018, Hawaii.

Grewal DS, Yoon SP, Polascik BW, Thompson AC, Burke J, Dunn C, Johnson K, Fekrat S. Retinal microvasculature and neurodegenerative changes among Alzheimer’s disease, mild cognitive impairment, and controls. AAO 2018, Chicago. 

Polascik BW, Thompson AC, Yoon SP, Burke J, Grewal DS, Fekrat S. Association of OCT angiography parameters with age in normal older adults. AAO 2018, Chicago. 

Wisely CE, Wang D, Henao R, Grewal DS, Yoon SP, Polascik BW, Thompson AC, Burke JR, Carin L, Fekrat S. Deep learning algorithm for diagnosis of Alzheimer’s disease using multimodal retinal imaging. ARVO 2019, Vancouver

Bhullar P, Pead E, Thompson AC, Yoon SP, Grewal DS, Polascik BW, Trucco E, MacGillivray T, Fekrat S. Multimodal retinal imaging Parkinson’s disease. ARVO 2019, Vancouver. 

Pead E, Grewal DS, Yoon SP, Polascik BW, Thompson AC, Burke JR, Dunn C, Trucco E, MacGillivray T, Fekrat S. Pilot study of ultra-widefield imaging to study the retinal vasculature in mild cognitive impairment and Alzheimer’s disease. ARVO 2019, Vancouver. 

Wisely CE, Grewal DS, Fekrat S. Deep learning algorithm for diagnosis of Alzheimer’s disease using multimodal retinal imaging. Residents’ and Fellows’ Day, Duke Eye Center, 2019. 

Bhullar P, Grewal S, Fekrat S. Evaluation of potential biomarkers in multimodal retinal images for diagnosis of Parkinson’s disease: pilot study. Residents’ and Fellows’ Day, Duke Eye Center, 2019. 

Cai S, Gray CD, Robbins C, Thompson AC, Yoon SP, Polascik BW, Hamid C, MacGillivray T, Fekrat S, Grewal DS. Optical coherence tomography angiography fractal dimension in Alzheimer’s disease, mild cognitive impairment, and age-matched cognitively healthy controls. ARVO, Baltimore, 2020 (cancelled due to COVID-19). 

Robbins C, Grewal DS, Thompson AC, Yoon SP, Plassman B, Fekrat S. Repeatability, interocular symmetry, and correlation with age of peripapillary optical coherence tomography angiography parameters in healthy eyes. ARVO, Baltimore, 2020 (cancelled due to COVID-19). 

Robbins CB, Grewal DS, Powers JH, Thompson AC, Polascik BW, Agrawal R, Fekrat S. Subfoveal choroidal thickness and choroidal vascularity index on spectral-domain optical coherence tomography in Alzheimer’s disease. Alzheimer’s Association International Conference, Amsterdam, 2020 (cancelled due to COVID-19). 

Robbins CB, Grewal DS, Bhullar PK, Thompson AC, Yoon SP, Polascik BW, Agrawal R, Fekrat S. Characterization of retinal microvascular and structural changes in Parkinson’s disease using optical coherence tomography angiography. Residents’ and Fellows’ Day, Duke Eye Center, 2020. 

Cai S, Gray CD, Robbins C, Thompson AC, Yoon SP, Polascik BW, Hamid C, MacGillivray T, Fekrat S, Grewal DS. Optical coherence tomography angiography fractal dimension in Alzheimer’s disease, mild cognitive impairment, and age-matched cognitively healthy controls. The Retina Society, 2020. 

Robbins CB, Grewal DS, Fekrat S. Characterization of retinal microvascular and choroidal structural changes in Parkinson's disease using optical coherence tomography angiography. AAO, 2020. 

Robbins CB, Grewal DS, Fekrat S. From eye to brain: correlating retinal and choroidal vascular parameters with volumetric MRI in Alzheimer’s disease and mild cognitive impairment. Duke VisionFest Virtual Symposium 2020.   

Mirzania D, Thompson AC, Robbins CB, Grewal DS, Fekrat S. Sex differences in retinal microvasculature and neurodegenerative changes in Alzheimer’s disease: a case-control study.Duke VisionFest Virtual Symposium 2020.   

Cai S, Robbins CB, Grewal DS, Fekrat S. OCT angiography multifractal analysis of Alzheimer’s disease, mild cognitive impairment, and healthy controls. Duke VisionFest Virtual Symposium 2020.   

Akrobetu D, Robbins CR, Stinnett SS, Soundararajan S, Liu A, Johnson K, Grewal DS, Fekrat S. Assessment of retinal microvascular alterations in individuals with amnestic and non-amnestic mild cognitive impairment using optical coherence tomography angiography. ARVO 2021. 

Robbins CR, Grewal DS, Wang D, Wisely CE, Henao R, Lee JM, Agrawal R, Soundararajan S, Thompson AC, Plassman B, Lad E, Whitson H, Carin L, Fekrat S. Analyzing the retinal and choroidal vasculature and structure in cognitively healthy individuals at higher genetic risk for Alzheimer’s disease using a convolutional neural network. ARVO 2021. 

Wisely CE, Robbins CR, Ma J, Kim T, Grewal DS, Fekrat S. Correlation of aqueous humor and plasma concentrations of amyloid and tau in older adults without dementia. ARVO, 2021. 

Ma J, Robbins CB, Pead E, McGrory S, Hamid C, Grewal DS, Scott BL, Trucco E, MacGillivray T, Fekrat S. Retinal vascular changes in Parkinson’s disease on ultra-widefield retinal imaging. ARVO 2021. 

Robbins CB, Grewal DS, Soundararajan S, Stinnett S, Liu A, Johnson KG, Fekrat S. Radial peripapillary capillary network microvascular changes in Alzheimer’s disease, mild cognitive impairment, and cognitively healthy controls. Alzheimer’s Association International Conference 2021. 

Mirzania D, Robbins CB, Thompson AC, Yoon SP, Liu A, Johnson KG, Grewal DS, Fekrat S. Retinal microvasculature and neurodegenerative changes in males vs females with Alzheimer’s disease: a case-control study. Alzheimer’s Association International Conference 2021. 

Akrobetu D, Robbins CB, Stinnett SS, Soundararajan S, Liu A, Johnson KG, Grewal DS, Fekrat S. Assessment of retinal microvascular alterations in individuals with amnestic and non-amnestic mild cognitive impairment using optical coherence tomography angiography. Alzheimer’s Association International Conference 2021. 

Rashid D, Bernabeu Llinares M, Cai S, Giarratano Y, Gray C, Hamid C, Grewal DS, Robbins CB, Soundararajan S, Ma J, Fekrat S, MacGillivray TJ. Reproducibility of retinal vascular phenotypes obtained with optical coherence tomography angiography: importance of vessel segmentation.Medical Image Understanding and Analysis (MIUA) conference 2021. 

Mirzania D, Robbins CB, Thompson AC, Yoon SP, Liu A, Johnson KG, Grewal DS, Fekrat S. Retinal and choroidal changes in males compared to females with Alzheimer’s disease: a case-control study. Women in Ophthalmology, 2021. 

Mirzania D, Robbins CB, Thompson AC, Yoon SP, Liu A, Johnson KG, Grewal DS, Fekrat S. Retinal and choroidal changes in males compared to females with Alzheimer’s disease: a case-control study. ASRS, San Antonio, 2021. 

Robbins CB, Wong D, Grewal DS, Wisely CE, Henao R, Soundararajan S, Ma J, Plassman B, Lad E, Whitson H, Carin L, Fekrat S. A convolutional neural network to identify cognitively healthy individuals at higher genetic risk for Alzheimer’s disease.  ASRS, San Antonio, 2021. 

Ma J, Robbins CB, Pead E, McGrory S, Hamid C, Grewal DS, Scott BL, Trucco E, MacGillivray T, Fekrat S. Investigating retinal vascular changes in Parkinson’s disease using ultra-widefield retinal imaging. ASRS, San Antonio, 2021. 

Akrobetu D, Robbins CB, Stinnett SS, Soundararajan S, Liu AJ, Johnson KG, Grewal DS, Fekrat S. Assessment of retinal microvascular alterations in individuals with amnestic and non-amnestic mild cognitive impairment using OCT angiography. ASRS, San Antonio, 2021. 

Robbins CB, Wisely CE, Singh P, Kim T, Grewal DS, Fekrat S. Quantifying neuronal biomarkers in aqueous humor in individuals undergoing routine cataract surgery and correlating with age and cognition. ASCRS, 2022. 

Akrobetu D, Robbins CB, Grewal DS, Fekrat S. Intrasession repeatability of macular optical coherence tomography angiography parameters in neurodegenerative disease. ARVO, 2022. 

Kundu A, Ma J, Robbins CB, Pant P, Soundararajan S, Stinnett S, Scott B, Moore K, Grewal DS, Fekrat S. Multimodal retinal imaging in Parkinson’s disease: A longitudinal analysis. ARVO, 2022. 
 
Kundu A, Ma J, Robbins CB, Pant P, Soundararajan S, Stinnett S, Scott B, Moore K, Grewal DS, Fekrat S. Differences in rate of change of retinal structural and microvasculature parameters in Parkinson’s disease compared to controls. ASRS, 2022. 

Kundu A, Ma J, Robbins CB, Pant P, Soundararajan S, Stinnett S, Scott B, Moore K, Grewal DS, Fekrat S. Differences in rate of change of retinal structural and microvasculature parameters in Parkinson’s disease compared to controls. Alzheimer’s Association International Conference (AAIC), 2022. 

Kundu A, Ma J, Robbins CB, Pant P, Soundararajan S, Stinnett S, Scott B, Moore K, Grewal DS, Fekrat S. Longitudinal Analysis of Retinal Structural and Microvascular Parameters in Parkinson’s Disease compared to Controls. Women in Ophthalmology (WIO) Summer Symposium, 2022. 

Kundu A, Ma J, Robbins CB, Pant P, Soundararajan S, Stinnett S, Scott B, Moore K, Grewal DS, Fekrat S. Differences in rate of change of retinal structural and microvasculature parameters in Parkinson’s disease compared to controls. Duke Ophthalmology Trainee Day, 2022.

Konda SM, Robbins C, Stinnett S, Ma J, Kundu A, Pant P, Mousa H, Agrawal R, Moore K, Grewal DS, Fekrat S. Analysis of retinal and choroidal changes in males and females with Parkinson’s disease using OCT and OCTA. Duke Ophthalmology Trainee Day, 2022. 

Justin G, Winslow L, Robbins CB, Pant P, Kundu A, Hsu ST, Boisvert CJ, Tagg NT, Stinnett S, Grewal DS, Fekrat S. Evaluating the retinal architecture and microvasculature in traumatic brain injury using OCTA. Duke Ophthalmology Trainee Day, 2022. 

Justin GA, Winslow L, Robbins CB, Pant P, Kundu A, Hsu ST, Boisvert CJ, Tagg NT, Stinnett SS, Grewal DS, Fekrat S. Evaluating the retinal architecture and microvasculature in traumatic brain injury using optical coherence tomography angiography. The Retina Society, Pasadena, 2022. 

Winslow L, Justin GA, Robbins CB, Pant P, Kundu A, Hsu ST, Boisvert C, Tagg NT, Stinnett SS, Grewal DS, Fekrat S. Evaluating the retinal structure and microvasculature in traumatic brain injury and concussion using multimodal retinal imaging. NCSEPS, Greensboro, 2022. 

Kundu A, Ma JP, Robbins CB, Pant P, Soundararajan S, Stinnett SS, Scott BL, Moore KP, Grewal DS, Fekrat S. Longitudinal analysis of retinal structural and microvasculature parameters in Parkinson disease compared to controls. NCSEPS, Greensboro, 2022. 

Robbins CB, Wisely CE, Singh P, Challa P, Kim T, Fekrat S. Quantifying aqueous and plasma levels of phosphorylated tau-181 in individuals undergoing cataract surgery. ASCRS ASOA 2023.

Lee T, Rivera A, Brune M, Haystead A, Winslow L, Kundu A, Kundu R, Grewal DS, Fekrat S. Convolutional neural network-based automated quality assessment of OCT and OCT angiography images in neurodegenerative diseases: iMIND study group. Vit-Buckle Society, Las Vegas, 2023.

Robbins CB, Justin G, Winslow L, Kundu A, Pant P, Hsu ST, Boisvert CJ, Tagg NT, Stinnett SS, Grewal DS, Fekrat S. Evaluating the retinal architecture and microvasculature in traumatic brain injury using optical coherence tomography angiography. Vit-Buckle Society, Las Vegas, 2023.

McIlwaine G, Csincsik L, Pead E, Hamid C, Threlfall A, Fekrat S, MacGillivray T, Crutch S, Peto T, Lengyel I. Retinal vascular changes in typical Alzheimer’s disease and posterior cortical atrophy using ultra-widefield retinal image analysis. ARVO 2023.

Konda SM, Robbins CB, Stinnett S, Ma J, Kundu A, Pant P, Mousa H, Agrawal R, Moore K, Grewal DS, Fekrat S. Assessment of gender-based differences in retinal and choroidal parameters in Parkinson’s disease. ARVO 2023.

Hemesath A, Kundu A, Allen A, Joseph S, Ma JP, Robbins CB, Stinnett SS, Grewal DS, Fekrat S. Longitudinal retinal findings in individuals with mild cognitive impairment over a two year period. ARVO 2023.

Winslow L, Joseph S, Allen A, Kundu A, Hemesath A, Robbins CB, Ma JP, Moore KPL, Stinnett SS, Grewal DS, Fekrat S. Characterizing the retinal microvasculature and structure in individuals with dementia with Lewy bodies. ARVO 2023.

Haystead A, Joseph S, Allen A, Kundu A, Hemesath A, Robbins CB, Ma JP, Moore KPL, Stinnett SS, Grewal DS, Fekrat S. Characterizing the retina structure and microvasculature in Huntington’s disease. ARVO 2023.

Robbins CB, Hemesath A, Kundu A, Allen A, Joseph S, Ma JP, Stinnett SS, Grewal DS, Fekrat S. Longitudinal differences in retinal structure and microvasculature in individuals with mild cognitive impairment. ASRS, Seattle, 2023.

Richardson A, Wisely CE, Henao R, Robbins CB, Ma JP, Wang D, Johnson KG, Liu AJ, Grewal DS, Fekrat S. A convolutional neural network using retinal imaging for identification of mild cognitive impairment in neurodegenerative disease. Duke Health Data Science Showcase 2023.

Allen A, Joseph S, Hemesath A, Kundu A, Robbins CB, Ma JP, Haystead A, Winslow L, Agrawal R, Johnson KG, Bozoki AC, Liu A, Stinnett SS, Grewal DS, Fekrat S. Angioarchitectural alterations in the retina and choroid in frontotemporal dementia. Women in Ophthalmology, Florida, 2023.

Allen A, Joseph S, Hemesath A, Kundu A, Robbins CB, Ma JP, Haystead A, Winslow L, Agrawal R, Johnson KG, Bozoki AC, Liu A, Stinnett SS, Grewal DS, Fekrat S. Angioarchitectural alterations in the retina and choroid in frontotemporal dementia. 53^rd Annual Duke Medical Student Research Symposium, 2023.

Hemesath A, Kundu A, Allen A, Joseph S, Ma JP, Robbins CB, Stinnett SS, Grewal DS, Fekrat S. Longitudinal retinal findings in individuals with mild cognitive impairment over a two year period. Alzheimer’s Association International Conference (AAIC), 2023.

Kundu R, Rivera A, Lee T, Kundu A, Grewal DS, Fekrat S. Development of a tool for the automatic assessment of retinal images. Health Data Science Showcase, Duke AI Health, Durham, 2023.

Cox M, Lee T, Kundu A, Kundu R, Haystead A, Joseph S, Henao RP, Grewal DS, Fekrat S.  Interpretable machine learning for automated quality assessment of optical coherence tomography (OCT) angiography, optic nerve head angiography, and enhanced depth imaging OCT images. Health Data Science Poster Showcase, Duke AI Health, Durham, 2023.

Karl JJ, Joseph S, Patel H, Weng P, Haystead A, Stinnett S, Kimbrough D, Grewal DS, Fekrat S. Reduced retinal vessel and perfusion densities in multiple sclerosis compared to controls. ARVO, Seattle, 2024.

Woo J, Joseph S, Robbins CB, Haystead A, Stinnett SS, Grewal DS, Fekrat S. Longitudinal rate of change of peripapillary optical coherence tomography angiography metrics in cognitively normal older adults. ARVO, Seattle, 2024.

Patel S, Karthik N, Justin G, Chiu SJ, Grewal DS, Fekrat S. Analyzing retinal layer structure in individuals with post traumatic stress disorder using OCT. ARVO, Seattle, 2024.

Karthik N, Patel S, Justin GA, Chiu SJ, Grewal DS, Fekrat S. Retinal architectural findings in traumatic brain injury using optical coherence tomography. ARVO, Seattle, 2024.

Lee T, Cox M, Kundu A, Haystead A, Joseph S, Kundu R, Henao R, Grewal DS, Fekrat S. Automated quality classification of OCT and OCT angiography image maps using convolutional neural network. ARVO, Seattle, 2024.

Rashid D, Giarratano Y, MacGillivray T, Engelmann J, Dhillon B, Ritchie C, Patel H, Kundu A, Grewal DS, Cai S, Fekrat S, Bernabeu M. Using latent diffusion models to generate synthetic OCTA images. ARVO, Seattle, 2024

Zhao W, Robbins CB, Allen A, Joseph S, Kundu A, Hemesath A, Petrella J, Grewal DS, Fekrat S. Exploring correlations between the retinal microvascular and volumetric MRI parameters in Alzheimer’s disease and mild cognitive impairment. ARVO, Seattle, 2024.

Patel H, Robbins CB, Wisely CE, Ma JP, Singh P, Challa P, Kim T, Grewal DS, Fekrat S. Correlation of aqueous and plasma levels of phosphorylated tau181 with age and Montreal Cognitive Assessment Scores in individuals undergoing cataract surgery. ARVO, Seattle, 2024. Invited to the Members-in-Training (MIT) Outstanding Poster Competition.

Lee T, Cox M, Kundu A, Haystead A, Joseph S, Kundu R, Henao R, Grewal DS, Fekrat S. Automated quality classification of OCT and OCT angiography image maps using convolutional neural network. Vit-Buckle Society, Miami, 2024.

Patel S, Karthik N, Justin G, Chiu SJ, Grewal DS, Fekrat S. Analyzing retinal layer structure in individuals with post traumatic stress disorder using OCT. Undergraduate Research Symposium, Duke University, Durham, 2024.

Patel S, Karthik N, Justin G, Chiu SJ, Grewal DS, Fekrat S. Analyzing retinal layer structure in individuals with post traumatic stress disorder using OCT. Undergraduate Research Symposium, Duke University, Durham, 2024.

Richardson A, Kundu A, Henao R, Lee T, Scott BL, Grewal DS, Fekrat S. A convolutional neural network to identify Parkinson’s disease using multimodal retinal images. ASRS 42^nd Annual Meeting, Stockholm, 2024

Karl JJ, Joseph S, Patel H, Weng P, Haystead A, Stinnett S, Kimbrough D, Grewal DS, Fekrat S. High-efficacy disease-modifying therapy protects retinal nerve fiber layer and ganglion cell layer-inner plexiform layer in patients with multiple sclerosis. ASRS 42^nd Annual Meeting, Stockholm, 2024.

Richardson A, Kundu A, Henao R, Lee T, Scott BL, Grewal DS, Fekrat S. A convolutional neural network to identify Parkinson’s disease using multimodal retinal images. Alzheimer’s Association International Conference (AAIC), 2024.

Woo J, Joseph S, Robbins CB, Haystead A, Stinnett SS, Grewal DS, Fekrat S. Longitudinal variations in retinal and neuronal degeneration in cognitively normal older adults using peripapillary optical coherence tomography angiography. Alzheimer’s Association International Conference (AAIC), 2024.

Joseph S, Haystead A, Robbins CB, Threlfall A, MacGillivray TJ, Stinnett S, Grewal DS, Fekrat S. Ultra-widefield retinal and choroidal vascular architecture in mild cognitive impairment and normal cognition. Alzheimer’s Association International Conference (AAIC), 2024.

Patel H, Robbins CB, Wisely CE, Ma JP, Singh P, Challa P, Kim T, Grewal DS, Fekrat S. Correlation of aqueous and plasma levels of phosphorylated tau181 with age and Montreal Cognitive Assessment Scores in individuals undergoing cataract surgery. Alzheimer’s Association International Conference (AAIC), 2024.

Richardson A, Kundu A, Henao R, Lee T, Scott BL, Grewal DS, Fekrat S. A convolutional neural network to identify Parkinson’s disease using multimodal retinal images. Ophthalmic Artificial Intelligence Summit, 2024.

2017          Duke study suggests earliest sign of Alzheimer’s could be linked to eye problems. 

Duke Health issued a press release on March 5, 2019 that received overwhelming coverage including the following:

2019          New study shows an eye scan can detect signs of Alzheimer’s disease.

2019          ENC Health Currents: Could Alzheimer’s be diagnosed with an eye exam? 

2019          New study shows an eye scan can detect signs of Alzheimer’s disease. 

2019          Eye scan can detect signs of Alzheimer’s disease. 

2019          Eye exam could soon detect Alzheimer’s, new study suggests. 

2019          2 studies use retinal scans to find early Alzheimer’s disease. 

2019          Alzheimer’s disease can be spotted through simple eye test. 

2019          Alzheimer’s disease could one day be diagnosed with an eye test. 

2019          Eye exams may someday detect Alzheimer’s disease. 

2019          Routine eye exam could one day diagnose Alzheimer’s before symptoms show, Duke doctors say. 

2019          Could an eye doctor diagnose Alzheimer’s before you have symptoms?

2019          Could an eye test help detect Alzheimer’s disease? 

Duke Health issued a press release on November 30, 2020 - AI Model Uses Retinal Scans to Predict Alzheimer's Disease

2020          AI model uses retinal scans to predict Alzheimer’s disease. 

2021          Eye changes may identify Parkinson’s disease. 

2021          Our eyes may provide early warning signs of Alzheimer’s and Parkinson’s 

2021          Eyes show early warning signs for Alzheimer’s. 

2021.         Show 1272: How Your Eyes Reveal Your Health

2023          WUNC-FM

2023          Machine learning model identifies mild cognitive impairment from retinal scans

2023          A new ML model can identify mild cognitive impairment from retinal scans

2023          Eye scans could offer early warning signs of Alzheimer’s disease, Duke researchers find

2023          Eye to the Mind: AI Pinpoints Cognitive Impairment via Retinal Images

2023         Can you see Alzheimer's disease on retina scan

2023         Retinal OCT Shows Promise as Diagnostic Aid for Mild Cognitive Impairment

2023         Duke Health Researchers Make Advancements in Eye Health

2023         Machine Learning Model Identifies Mild Cognitive Impairment from Retinal Scans

2017                Second place, Trainee (Mentees Stephen Yoon and Bryce Polascik) poster competition, Retinal Microvasculature in Identical Twins, NC Society of Eye Physicians and Surgeons 

2018                Karen L Wrenn Alzheimer’s Disease Travel Award (Mentee Stephen Yoon BS), Retinal Microvasculature and Neurodegenerative Changes Among Alzheimer’s Disease, Mild Cognitive Impairment, and Controls 

2019                Karen L Wrenn Alzheimer’s Disease Travel Award (Mentee Cason Robbins BS), Longitudinal Analysis of Retinal Microvascular Changes Associated with CSF Amyloid-Beta Levels in Patients with Mild Cognitive Impairment 

2019                VitreoRetinal Surgery Foundation (VRSF) Award (Mentee Sophie Cai MD), Optical Coherence Tomography Angiography Fractal Dimension in Alzheimer’s Disease. 

2019                VitreoRetinal Surgery Foundation (VRSF) Award (Mentee C. Ellis Wisely MD MBA), A Deep Learning Model Using Multimodal Retinal Imaging for Detection of Patients with Genetic Predisposition for Development of Alzheimer’s Disease 

2020                Robert Machemer Resident Research Award (Mentee C. Ellis Wisely MD MBA), Correlation of aqueous humor concentrations of amyloid, tau, and neurofilament light chain with serum concentrations in cognitively normal older adults 

2020                VitreoRetinal Surgery Foundation (VRSF) Award (Mentee Justin Ma BS), Differential multimodal retinal imaging in biomarker positive subjects with Alzheimer's disease and mild cognitive impairment characterized by neuroimaging and neurochemical analysis 

2021                Gerhard Zinser Memorial (ARVO) Travel Grant for Dennis Akrobetu’s project titled Assessment of retinal microvascular alterations in individuals with amnestic and non-amnestic mild cognitive impairment using optical coherence tomography angiography 

2021                Retina Research Foundation/Joseph M. and Eula C. Lawrence (ARVO) Travel Grant for Cason Robbins’ project titled Analyzing the retinal and choroidal vasculature and structure in cognitively healthy individuals at higher genetic risk for Alzheimer’s disease using a convolutional neural network 

2021                Research to Prevent Blindness Small Grant Award, Duke Eye Center (Mentee Cason Robbins BS), Correlating retinal and choroidal microvascular parameters with volumetric MRI in Alzheimer’s disease and mild cognitive impairment  

2021                Research to Prevent Blindness Small Grant Award, Duke Eye Center (Mentee C. Ellis Wisely MD MBA), Correlation of aqueous humor and serum protein concentrations of amyloid, tau, neurofilament light chain, and alpha-synuclein with neurodegenerative disease

2021                VitreoRetinal Surgery Foundation (VRSF) Award (Mentee Grant Justin MD), Evaluating the Retinal Structure and Microvasculature in Mild and Moderate Traumatic Brain Injury using Multimodal Retinal Imaging   

2021                Research to Prevent Blindness Medical Student Eye Research Fellowship (Mentee Praruj Pant BS), A cross-sectional study of multimodal ophthalmic imaging in three well-characterized cohorts Alzheimer’s disease, mild cognitive impairment, controls - from the Duke-University of North Carolina Alzheimer’s Disease Research Collaborative 

2022                Research to Prevent Blindness Small Grant Award, Duke Eye Center (Mentee Anita Kundu BS), Longitudinal analysis of multimodal retinal and choroidal imaging in Parkinson’s disease. 

2022                2nd place (Mentee Anita Kundu), Longitudinal analysis of retinal structural and microvasculature parameters in                          Parkinson disease compared to controls, Poster Competition, NC Society of Eye Physicians and Surgeons

2023               Academic Grant Award (Mentee Cason B. Robbins MD), Vit-Buckle Society, Evaluating the retinal architecture and microvasculature in traumatic brain injury using optical coherence tomography angiography

2023                Undergraduate Research Support Assistantship Funding (Mentee Sejal Patel)

2023                VitreoRetinal Surgery Foundation Award (Mentee Jamie Karl BS), Longitudinal analysis of optical coherence tomography (OCT) and OCT angiography in patients with multiple sclerosis

2024                Duke Undergraduate Conference Grant (Mentee Sejal D Patel), Analyzing retinal layer structure in individuals with post traumatic stress disorder using OCT

2024        Undergraduate Research Support Assistantship Funding (Mentee Sejal Patel) 

2024        National Eye Institute ARVO Travel Grant (Mentee Hemal Patel BS), Correlation of aqueous and plasma levels of phosphorylated tau181 with age and Montreal Cognitive Assessment Scores in individuals undergoing cataract surgery. 

2024                Research to Prevent Blindness Small Grant Award from Duke Eye Center (Mentee Hemal Patel BS), Correlation of cerebrospinal fluid amyloid and tau with retinal imaging metrics in cognitively normal individuals.

2024               Michelle P. Winn Inclusive Excellence Award 

Supported in part by the Alzheimer's Drug Discovery Foundation 2019-2021